Smart Surgical Probe for

Brain Tumor Delineation

Smart Surgical Probe for

Brain Tumor Delineation

Smart Surgical Probe for

Brain Tumor Delineation

The research aims to create a new tool to help neurosurgeons identify brain tumour margins more accurately. This is essential as any residual tumour in the brain after surgery can lead to the recurrence of tumours, causing the patient’s survival chances to reduce considerably. The brain tumour margin delineation probe combines two imaging techniques: electrical impedance tomography (EIT) and ultrasound. These two techniques give doctors complementary information about the tissue being imaged, providing a clearer picture of the tumour location. The EIT system being developed for this probe will be able to image the surface of the brain and a few millimeters underneath it. The ultrasound part of the tool will use cutting-edge techniques called elastography and H-Scan, which will help create a detailed map of the tumour’s shape and location, improving the resolution and accuracy. The researchers will be working with doctors and other experts to ensure that the probe is designed to meet the needs of medical professionals. The effectiveness of the probe will be tested in tissue samples and animal models with brain tumours. The successful completion of the proposed work could help doctors more safely and effectively remove brain tumours, with significant benefits for patients.

About

We, a group of researchers from IISc Bangalore, IIT Gandhinagar, and NIMHANS Bangalore, are collaborating to merge biology/medicine with microtechnology, nanotechnology, and additive manufacturing. We aim to develop innovative tools addressing unmet clinical challenges. Currently, our research emphasizes flexible sensors, microsensors, microfluidic devices, and microelectromechanical systems, with a focus on cancer diagnosis, E-Nose, cardiovascular pathology, neuroprotective therapies for stroke, Parkinson’s and epilepsy, neuroinfections and prion diseases, neuroinflammatory disorders, epilepsy pathology, developmental neuropathology, peripheral neuropathies, meningiomas, brain abscesses, gangliogliomas, therapeutic ultrasound, nonlinear imaging, ultrasound contrast agents, ultrasound-assisted drug delivery, intravascular imaging and therapy, medical device development, tissue elasticity imaging, shear wave imaging, quantitative ultrasound techniques, high-frequency ultrasound imaging, and tissue characterization. These multidisciplinary efforts leverage expertise from diverse technical fields.
Dr Hardik J Pandya

Dr Hardik J Pandya

Lead Principal Investigator

Indian Institute of Science, Bangalore

Dr Anita Mahadevan

Dr Anita Mahadevan

Co-Investigator

National Institute of Mental Health and Neurosciences, Bangalore

Dr Manish Beniwal

Dr Manish Beniwal

Co-Investigator

National Institute of Mental Health and Neurosciences, Bangalore

Dr Karla P Mercado-Shekhar

Dr Karla P Mercado-Shekhar

Co-Investigator

Indian Institute of Technology, Gandhinagar

Dr Himanshu Shekhar

Dr Himanshu Shekhar

Co-Investigator

Indian Institute of Technology, Gandhinagar

Dr. Vikas Vazhayil

Dr. Vikas Vazhayil

Co-Investigator

National Institute of Mental Health and Neurosciences, Bangalore

Dr. Shilpa Rao

Dr. Shilpa Rao

Co-Investigator

National Institute of Mental Health and Neurosciences, Bangalore

News and Updates

Recent Publications

  1. Rashmi Hulimane Shivaswamy, Pranav Binulal, Aloysious Benoy, Kaushik Lakshmiramanan, Nitu Bhaskar, Hardik Jeetendra Pandya: Microneedles as a Promising Technology for Disease Monitoring and Drug Delivery. A Review, ACS Materials Au, 2024. DOI: https://doi.org/10.1021/acsmaterialsau.4c00125%20
    Category: Journal articles